Stepanov Yu. M., Zygalo E. V., Stoikevich M. V., Sorochan O. V. SMALL INTESTINE MICROBIOTES IN PATIENTS WITH CHRONIC BOWEL DISEASES DEPENDING ON THEIR NUTRITIONAL STATUS

State institution "Institute of Gastroenterology of the NAMS Ukraine", 490074 Dnepropetrovsk

To assess the syndrome of bacterial overgrowth (SBOG), we performed the hydrogen respiratory test (HRT) with glucose in 70 patients with evidence of inflammatory bowel disease (IBD): 43 patients with ulcerative colitis (UC) and 27 patients with Crohn's disease (CD). The obtained results were analyzed relative their nutritional status. 83.8 % of the patients displayed definite disorders: nutritional deficiency (58.8 %) and excessive fat mass (25.0 %). A marked nutritional deficiency was registered 1.3-fold more often (P < 0.05) and was more pronounced (P < 0.05) at CD versus UC and was associated with the severe course of disease (r = —0.39, P = 0.01). According to the results of HRT, 52.9 % of study patients with IBD had disturbances in the small intestine microbiocenosis in the form of SBOG. These disorders were statistically dependent on nutritional status and prevailed in the patients with nutritional deficiency (78.7 %).

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