Chagarovsky А. P., Gavalko Yu. V.*, Sineok L. L.*, Romanenko M. S.*, Naumchuk N. S.* CORRECTION OF LIPID AND CARBOHYDRATE METABOLISM IN THE ELDERLY WITH METABOLIC SYNDROME USING PROBIOTIC CULTURES

LLC "Chr.Hansen Ukraine", 08130 Kyiv
*State institution "D. F. Chebotarev Institute of Gerontology NAMS Ukraine", 04114 Kyiv

Altogether 70 elderly subjects aged 60—74 years with metabolic syndrome (MS) took part in the study. They were divided into 3 groups: group 1 (control) – elderly subjects with MS and without intestinal dysbiosis (n = 20), group 2 (basic) – elderly subjects with MS and intestinal dysbiosis (n = 41), group 3 (additional) – elderly subjects with MS and without intestinal dysbiosis (n = 9). All of them received probiotic cultures in the dose of 3.0x108 of CFU Bifidobacterium lactis BB12 and 1.3x108 of CFU Lactobacillus acidophilus LA5 three times a day with meals for 30 days. The followings were tested: bacteriological examination of feces for dysbacteriosis with specific identification of isolated microorganisms; hematology; blood chemistry; and standard oral glucose tolerance test. After the use of probiotic cultures, there was a significant decrease in the total cholesterol, low density lipoprotein (LDL) cholesterol and atherogenic index and an increase level of high density lipoprotein (HDL) in the gr.1 patients. In addition, those of them who at baseline had triglyceride levels higher 1.7 mmol/l, they were also statistically decreased. The patients whose baseline glucose level was higher than 5.5 mmol/l, it practically did not change under the influence of probiotic cultures, while at the baseline glucose level less than 5.5 mmol/l it increased within age norm. Also, we registered a statistically significant increase of the total protein and a decrease of the blood serum creatinine level. In the additional group there were no statistically significant changes in the biochemical parameters and lipid profile, although a tendency was seen in lowering of LDL and atherogenesis index and increasing of HDL. Based on the results of the glucose tolerance test, 67% of study patients showed improved glucose tolerance, namely decrease of blood glucose to normal levels after 2 hours of glucose (75.75 g) administration. Summing up, intake of the probiotic cultures Lactobacillus acidophilus LA5 b and Bifidobacterium lactis BB12 promotes metabolic profile improvement in the elderly patients with metabolic syndrome, being especially pronounced in the presence of intestinal dysbiosis.

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