Beliaeva L. Eu., Fedchenko A. N., Lihetskaia I. V., Halinskaia K. B. PATHOPHYSIOLOGICAL SUBSTANTIATION FOR USING NUTRACEUTICALS BASED ON FISH OIL FOR PREVENTION OF OUTCOMES INDUCED BY PRENATAL STRESS

EE "Vitebsk State Order of Peoples’ Friendship Medical University", 210023 Vitebsk, Republic of Belarus

Administration of fish oil rich in w-3 polyunsaturated fatty acids – 60 mg/(kg×day) – to pregnant rats with modelled chronic unpredictable stress significantly decreased maternal cannibalism level during first 10 days after delivery, promoted decrease of expressiveness of behavioral disorders of their 3-month offspring in the "open field" test, increased the time of motionless contact of offspring’s tails with low-intensive and middle-intensive heat source and time of their location on the adjustable roller of rotarod, with more efficacy in female, rather than male offspring. Administration of fish oil to pregnant rats exposed to chronic stress resulted in a statistically significant decline of elevated blood pressure in prenatally stressed rats. The mechanisms of protective effect of w-3 polyunsaturated fatty acids are discussed.

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