Коliada А. К., Sosedko А. S., Chivlikly М. А., Vaiserman А. М., Каraban I. N. Mutations of LRRK2, GBA and SNCA genes, associated with Parkinson’s disease in cttizens of Ukraine

Problems of Aging and Development, 2015, vol. 24, № 1.- P. 14-20.

MUTATIONS OF LRRK2, GBA and SNCA GENES, ASSOCIATED WITH PARKINSON'S DISEASE IN CITIZENS OF UKRAINE
А. К. Коliada, А. S. Sosedko*, М. А. Chivlikly, А. М. Vaiserman, I. N. Каraban
State Institution "D. F. Chebotarev Institute of Gerontology NAMS Ukraine", 04114 Kyiv
*Institute of High Technologies of Kyiv National Taras Shevchenko University, 02033 Kyiv

Genotyping for LRRK2, GBA and SNCA genes in 216 patients aged 54-79 with Parkinson's disease (PD) and 300 neurologically healthy subjects aged 50-83 (control group), living in various parts of Ukraine, revealed the occurrence of LRRK2 g.40734202GA, GBA c.1226AG and c.483TC genes to be in 1.85 %, 2.31 % and 1.85 % of PD patients. No such genes were identified in subjects of control group. No c.209G>A mutations in SNCA gene were identified in both groups. The data obtained showed the occurrence of mutation in the genes associated with PD in citizens of Ukraine to be peculiar for countries of Eurasia.